By sequentially inflating, expanding, squeezing, and deflating the multi-chamber inflatable sleeves the circulatory compression to the leg, foot or both simultaneously arise. It not only facilitates the blood flow velocity, removes the blood clotting behind the venous valve leaflets, reduces blood stagnation, improves blood circulation and interstitial fluid, prevents the aggregation of coagulation factors and adhesion to the intima, but also increases the activity of the fibrinolytic system, causing changes in hemodynamics and fibrinolytic system, thus achieving the purpose of preventing deep vein thrombosis (DVT) and relieving peripheral edema (PE).